| Expression pattern: |
DS |
| Associated gene: |
beta-catenin |
| Associated microRNA: |
hsa-miR-3619-5p, hsa-miR-4741 |
| Biological function: |
May influence the development of SGA; predicted to regulate the Wnt/beta-catenin pathway through hsa-miR-3619-5p. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving hsa_circRNA15994-13, hsa-miR-3619-5p and beta-catenin/Wnt signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Differential expression in umbilical cord and maternal blood plasma may provide a basis for predicting fetal plasma content in maternal plasma and may provide new mechanism ideas and control targets for SGA. |
| Description: |
hsa_circRNA15994-13 was differentially expressed in SGA, with increased levels in umbilical cord and maternal plasma and decreased levels in SGA placental tissue. The study predicts that it may act through a hsa_circRNA15994-13/hsa-miR-3619-5p/beta-catenin regulatory network affecting Wnt/beta-catenin signaling in SGA. |
| Confidence score: |
0.6193 |