| Expression pattern: |
DN |
| Associated gene: |
RGMB, Ago2 |
| Associated microRNA: |
miR-582-3p |
| Biological function: |
Suppresses NSCLC cell proliferation, migration and invasion and promotes apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-582-3p to up-regulate RGMB expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circ_0001073 expression is associated with longer survival time in NSCLC patients. |
| Description: |
circ_0001073 is down-regulated in NSCLC and acts as a tumor suppressor by inhibiting proliferation/migration/invasion and promoting apoptosis. Mechanistically, it sponges miR-582-3p to relieve repression of RGMB, forming a circ_0001073/miR-582-3p/RGMB axis; higher circ_0001073 levels correlate with longer patient survival. |
| Confidence score: |
0.8252 |