| Expression pattern: |
UP |
| Associated gene: |
HK2 |
| Associated microRNA: |
miR-188-5p |
| Biological function: |
circ-PRMT5 promotes HCC cell proliferation, migration, glycolysis and tumor growth in vivo. |
| Molecular mechanism: |
circ-PRMT5 acts as a sponge of miR-188-5p to positively regulate HK2 expression via the circ-PRMT5/miR-188-5p/HK2 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ-PRMT5 might be a potential therapeutic target for HCC treatment. |
| Description: |
circ-PRMT5 is upregulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, glycolysis and xenograft tumor growth by sponging miR-188-5p and increasing HK2 expression, suggesting the circ-PRMT5/miR-188-5p/HK2 axis as a potential therapeutic target. |
| Confidence score: |
0.7785 |