| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, AGO2 |
| Associated microRNA: |
miR-296-3p, miR-382-5p, miR-326 |
| Biological function: |
Suppresses ccRCC metastasis by inhibiting migration and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-296-3p, restoring E-cadherin expression (preventing E-cadherin mRNA degradation) to inhibit migration/invasion and metastasis. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Western Blot; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ-AKT3 expression level significantly correlated with ccRCC Fuhrman grade and was negatively related to the degree of malignancy at diagnosis. |
| Description: |
circ-AKT3 (hsa_circ_0017252), derived from AKT3, is down-regulated in ccRCC tissues and cell lines. It inhibits ccRCC migration/invasion and in vivo metastasis mainly by sponging miR-296-3p to restore E-cadherin (CDH1) expression, forming a circ-AKT3/miR-296-3p/E-cadherin ceRNA axis. |
| Confidence score: |
0.8314 |