circRNA basic information
circBase ID: hsa_circ_0008450
Name: hsa_circ_CMTM3
Synonym: circ_0008450 / circ-CMTM3
Host Gene: CMTM3
Genomic location(hg19): chr16:66642211-66643906:+
Genomic location(hg38): chr16:66608308-66610003:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NPC specimens; paired adjacent non-tumor specimens
Cell lines:

HK-1; 5-8F; C666-1; SUNE-1; NP69
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCL9
Associated microRNA: miR-577
Biological function: circ_0008450 acts as an oncogene in NPC; it promotes cell proliferation, migration and invasion, and inhibits apoptosis.
Molecular mechanism: circ_0008450 functions through a ceRNA mechanism by sponging miR-577, thereby relieving miR-577-mediated repression of CXCL9 and upregulating CXCL9 expression.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

circ_0008450 may provide a new therapeutic target for treating NPC.
Description:

circ_0008450 is up-regulated in NPC tissues and cell lines and acts as an oncogenic circRNA. It promotes NPC cell proliferation, migration and invasion while suppressing apoptosis by sponging miR-577 and increasing CXCL9 expression through the miR-577/CXCL9 axis.
Confidence score:

0.6536
Other information
Title:

Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma.

Journal: Experimental and molecular pathology
Published: 2019
PubMed ID: 31344361
Study type:

combined biological and clinical study
Data availability: Supplementary Table S1; Supplementary Table S2; https://doi.org/10.1016/j.yexmp.2019.104288
Code availability: -