| Expression pattern: |
UP |
| Associated gene: |
MTA3, metastasis-associated protein 3 |
| Associated microRNA: |
miR-766-3p |
| Biological function: |
circ_0021093 promotes HCC cell proliferation, migration and invasion, inhibits cell apoptosis, and is associated with larger tumor size, advanced TNM stage, lower differentiation grade and unfavorable prognosis. |
| Molecular mechanism: |
circ_0021093 acts as a ceRNA/miRNA sponge for miR-766-3p, thereby relieving suppression of MTA3 and promoting HCC progression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Upregulated circ_0021093 was related to adverse clinical characteristics and unfavorable prognosis, and circ_0021093 was identified as an independent prognostic predictor for HCC patients. |
| Description: |
circ_0021093 is upregulated in HCC tissues and cell lines and its high expression predicts poor overall survival. Functionally, it promotes HCC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0021093 sponges miR-766-3p to increase MTA3 expression, forming a circ_0021093/miR-766-3p/MTA3 regulatory axis. |
| Confidence score: |
0.7408 |