circRNA basic information
circBase ID: hsa_circ_0087961
Name: hsa_circ_LPAR1
Synonym: circ_0087961
Host Gene: LPAR1
Genomic location(hg19): chr9:113734352-113773970:-
Genomic location(hg38): chr9:110972072-111011690:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008661
MONDO name: vitiligo
Disease details: vitiligo
Disease DO ID:
 12306
Disease MeSH ID:
 D014820
Disease NCIt ID:
 C26915
Disease ICD11 ID:
 1894744640
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

skin tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PXN
Associated microRNA: hsa-miR-27a-3p
Biological function: might play an important regulatory role in the pathology of vitiligo
Molecular mechanism: ceRNA mechanism via hsa-miR-27a-3p targeting PXN (PAXILLIN)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0087961 (circ_0087961) is down-regulated in vitiligo skin by circRNA-seq. It was proposed to act in a ceRNA axis with hsa-miR-27a-3p and PXN (PAXILLIN) and may play an important regulatory role in vitiligo pathology, but this specific circRNA was not RT-qPCR-validated in the paper.
Confidence score:

0.3991
Other information
Title:

Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 33968138
Study type:

combined biological and clinical study
Data availability: PRJNA712982
Code availability: -