| Expression pattern: |
DN |
| Associated gene: |
ARHGAP24, AGO2, LMO7 |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
Suppresses osteosarcoma cell proliferation, migration and invasion, and promotes apoptosis; exosome-transmitted circ-LMO7 suppresses OS cell viability. |
| Molecular mechanism: |
Acts as a ceRNA sponging miR-21-5p to upregulate ARHGAP24; present in exosomes enabling intercellular transfer. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); FISH / smFISH; IF (Immunofluorescence); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
circ-LMO7 (hsa_circ_0088259) is down-regulated in osteosarcoma cells/tissues and functions as a tumor suppressor. It is mainly cytoplasmic and can be packaged into exosomes; it sponges miR-21-5p to relieve repression of ARHGAP24, thereby inhibiting OS cell proliferation, migration and invasion and promoting apoptosis. |
| Confidence score: |
0.7922 |