| Expression pattern: |
UP |
| Associated gene: |
YAP / yesassociated protein |
| Associated microRNA: |
miR-1180 |
| Biological function: |
circ-CDYL promotes multiple myeloma cell viability, DNA synthesis, aggressive progression and in vivo tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ-CDYL acts as a cytoplasmic miRNA sponge for miR-1180, relieving miR-1180-mediated repression of YAP and increasing YAP expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); Hippo/YAP (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-CDYL has diagnostic and prognostic efficacy in multiple myeloma; plasma circ-CDYL showed an AUC of 0.8996 for diagnosis, and high circ-CDYL was linked to advanced ISS and DS stage and shorter survival time. |
| Description: |
circ-CDYL is up-regulated in multiple myeloma tissues and plasma and is associated with advanced stage, diagnostic potential, and poor survival. It promotes MM cell growth and in vivo tumor progression by acting as a cytoplasmic sponge for miR-1180, thereby increasing YAP expression through the circ-CDYL/miR-1180/YAP axis. |
| Confidence score: |
0.8521 |