| Expression pattern: |
DN |
| Associated gene: |
RBM38, EIF4A3, PTEN pre-mRNA |
| Associated microRNA: |
miR-1289 |
| Biological function: |
circPTEN functions as a tumor suppressor in HCC by inhibiting cell proliferation, migration, invasion, EMT, primary tumor growth, and metastatic spread. |
| Molecular mechanism: |
circPTEN acts as a ceRNA/miRNA sponge for miR-1289, relieving miR-1289-mediated suppression of RBM38; EIF4A3 negatively regulates circPTEN biogenesis by interacting with PTEN pre-mRNA/circPTEN precursor RNA. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; CCK8; EdU Staining; Transwell Assay; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Low circPTEN expression is associated with poorer overall survival and correlates with poorly differentiated tumors, advanced TNM stages, and lymph node metastasis; circPTEN may serve as a prognostic biomarker and biomarker for HCC progression. |
| Description: |
circPTEN is downregulated in HCC tissues and low expression is associated with poorer survival and aggressive clinicopathological features. Functionally, circPTEN suppresses HCC proliferation, migration, invasion, EMT, tumor growth, and metastasis. Mechanistically, EIF4A3 negatively regulates circPTEN biogenesis, while circPTEN acts as a miR-1289 sponge to relieve suppression of RBM38. |
| Confidence score: |
0.8066 |