| Expression pattern: |
UP |
| Associated gene: |
RUVBL1, beta-catenin, LEF1, TIP60, C-myc |
| Associated microRNA: |
miR-370-3p, miR-877-3p |
| Biological function: |
promotes osteosarcoma cell proliferation, migration, invasion, EMT, tumorigenesis and metastasis |
| Molecular mechanism: |
circMYO10 functions as a miRNA sponge to inhibit miR-370-3p, thereby upregulating RUVBL1, promoting interaction of RUVBL1 with the beta-catenin/LEF1 complex, enhancing TIP60-associated chromatin remodeling and H4K16 acetylation at the MYC promoter, and activating Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
B
H
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Northern Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; IF (Immunofluorescence); Co-IP; ChIP / ChIP-seq; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Rescue Experiments |
| Clinical significance: |
potential value as a biomarker to predict the prognosis of patients with OS; potential therapeutic target for osteosarcoma treatment |
| Description: |
circMYO10 is upregulated in osteosarcoma and promotes proliferation, EMT, and metastasis. Mechanistically, it sponges miR-370-3p (and also binds miR-877-3p), relieving repression of RUVBL1 and enhancing beta-catenin/LEF1-driven Wnt signaling and MYC transcription via TIP60-associated chromatin remodeling and H4K16 acetylation. |
| Confidence score: |
0.8834 |