circRNA basic information
circBase ID: hsa_circ_0109320
Name: hsa_circ_ZNF91
Synonym: hsa_circ_0109320_CBC1
Host Gene: ZNF91
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma samples; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential plasma biomarker for predicting gefitinib efficacy and prognosis in gefitinib-treated NSCLC patients; elevated expression is associated with longer PFS.
Molecular mechanism: No regulatory mechanism was experimentally elucidated; the study focused on plasma expression profiling and biomarker performance for gefitinib efficacy.
Biological pathway or process:

drug resistance (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated hsa_circ_0109320 was associated with longer PFS and better prognosis in gefitinib-treated NSCLC patients; AUC for estimating gefitinib therapeutic effect was 0.81.
Description:

hsa_circ_0109320 was identified in plasma as a gefitinib efficacy-associated circRNA in NSCLC. Its elevated expression was validated by RT-qPCR and was associated with longer PFS, suggesting value as a non-invasive biomarker for EGFR-TKI response and prognosis.
Confidence score:

0.6895
Other information
Title:

Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer.

Journal: Journal of thoracic disease
Published: 2019
PubMed ID: 31285870
Study type:

combined clinical and bioinformatics study
Data availability: -
Code availability: -