| Expression pattern: |
UP |
| Associated gene: |
Apelin |
| Associated microRNA: |
miR-637 |
| Biological function: |
circ-NOTCH1 enhances gastric cancer cell proliferation and invasion and reduces cell apoptosis. |
| Molecular mechanism: |
circ-NOTCH1 acts as a sponge of miR-637, inhibits miR-637 transcriptional activity, and upregulates the miR-637 target gene Apelin. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; BrdU; Annexin V/PI Flow Cytometry; Transwell Assay |
| Clinical significance: |
- |
| Description: |
circ-NOTCH1 is up-regulated in gastric cancer cells and tissues. It functions as a miR-637 sponge to relieve repression of Apelin, thereby promoting gastric cancer cell proliferation and invasion while reducing apoptosis. |
| Confidence score: |
0.6521 |