| Expression pattern: |
UP |
| Associated gene: |
MMP16 |
| Associated microRNA: |
miR-127-5p, miR-145-5p, miR-585-3p, miR-758-3p |
| Biological function: |
promotes NSCLC cell proliferation, migration, and invasion |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-127-5p/miR-145-5p/miR-585-3p/miR-758-3p, thereby upregulating MMP16. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; BrdU; Transwell Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0002360 expression predicted a short overall survival time for NSCLC patients. |
| Description: |
circ_0002360 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, and invasion of NSCLC cells. It functions as a ceRNA that sponges miR-127-5p, miR-145-5p, miR-585-3p, and miR-758-3p to increase MMP16 expression, and high circ_0002360 correlates with shorter overall survival. |
| Confidence score: |
0.7444 |