circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005140
MONDO name: ovarian carcinoma
Disease details: epithelial ovarian cancer / EOC
Disease DO ID:
 4001
Disease MeSH ID:
 -
Disease NCIt ID:
 C4908
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

EOC tissues; adjacent noncancerous tissues
Cell lines:

A2780; HO-8910; SKOV3; CAOV3; HOEC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circHIPK3 is up-regulated in EOC tissues and ovarian cancer cell lines, is associated with lymph node invasion and advanced FIGO stage, and acts as a prognostic marker for EOC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

Higher circHIPK3 expression is associated with lymph node invasion, advanced FIGO stage, shorter DFS and OS, and is an independent poor prognostic factor in EOC patients.
Description:

This study found that circHIPK3 is up-regulated in EOC tissues and ovarian cancer cell lines. Higher circHIPK3 expression is associated with lymph node invasion, advanced FIGO stage, shorter DFS and OS, and independently predicts poor prognosis, suggesting its value as a prognostic biomarker for EOC.
Confidence score:

0.4758
Other information
Title:

CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 29949144
Study type:

combined biological and clinical study
Data availability: -
Code availability: -