circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: CircMTO1
Host Gene: MTO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tumor tissues; adjacent normal tissues
Cell lines:

HOK; SCC-9; SCC-15; CAL-27; HSC-3; HSC-6
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ATRX, ZNF460, AGO2
Associated microRNA: miR-320a, miR-9-3p
Biological function: promotes OSCC cell proliferation, migration, and invasion
Molecular mechanism: circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a; circMTO1 is transcriptionally regulated by ZNF460
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Western Blot; ChIP / ChIP-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circMTO1 is upregulated in OSCC tissues and cell lines and promotes OSCC cell proliferation, migration, and invasion. Mechanistically, circMTO1 acts as a ceRNA by sponging miR-320a to increase ATRX expression, and its expression is transcriptionally induced by ZNF460.
Confidence score:

0.8519
Other information
Title:

Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis.

Journal: Bioengineered
Published: 2021
PubMed ID: 34738503
Study type:

combined biological and clinical study
Data availability: The datasets and materials used in this study are available based on reasonable requested.
Code availability: -