circRNA basic information
circBase ID: hsa_circ_0007874
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: MTO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; human normal tissues; cervical cancer tumors
Cell lines:

HeLa; CaSki; C-33A; C-4 II; SiHa; Ect1/E6E7; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: S100A1, Beclin1, p62
Associated microRNA: miR-6893
Biological function: Promotes cervical cancer tumorigenesis, tumor growth, migration, invasion and cisplatin chemoresistance; inhibits cisplatin-induced apoptosis.
Molecular mechanism: circMTO1 acts as a ceRNA for miR-6893, regulating S100A1 and autophagy signaling to promote tumorigenesis and chemoresistance in cervical cancer.
Biological pathway or process:

ceRNA regulation (promotes); autophagy (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; MTT; TUNEL; Western Blot; In Vivo Animal Model
Clinical significance:

Potential therapeutic target and biomarker for cervical cancer.
Description:

circMTO1 is up-regulated in cervical cancer cells and tumors. It promotes cervical cancer migration, invasion, tumor growth and cisplatin chemoresistance by sponging miR-6893 and regulating S100A1 and autophagy-related signaling. The study suggests circMTO1 may serve as a therapeutic target and biomarker for cervical cancer.
Confidence score:

0.5634
Other information
Title:

circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2019
PubMed ID: 31226633
Study type:

combined biological and clinical study
Data availability: TCGA; NCI data portal (https://tcga-data.nci.nih.gov); Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.biopha.2019.109064
Code availability: -