circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: Circular RNA ZFR
Host Gene: ZFR
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; corresponding adjacent normal lung tissues
Cell lines:

HBE; A549; H460; H1703; PC9; H1299; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CUL4B
Associated microRNA: miR-101-3p
Biological function: circZFR exhibits a carcinogenic role in NSCLC; knockdown of circZFR inhibits NSCLC cell proliferation, migration and invasion.
Molecular mechanism: circZFR acts as a miR-101-3p sponge to promote CUL4B expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circZFR is upregulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, circZFR sponges miR-101-3p to enhance CUL4B expression, thereby promoting NSCLC cell proliferation, migration and invasion.
Confidence score:

0.6777
Other information
Title:

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression.

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 31407591
Study type:

combined biological and clinical study
Data availability: -
Code availability: -