| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-15b-3p, hsa-miR-141-5p, hsa-miR-197-3p, hsa-miR-205-3p, hsa-miR-670-3p |
| Biological function: |
Diagnostic biomarker that discriminates HBV-related HCC from cirrhosis and healthy controls. |
| Molecular mechanism: |
Predicted miRNA-binding (potential miRNA sponge/miRNA carrier function); no functional mechanism experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma hsa_circ_0027089 can discriminate HBV-related HCC from HBV-related cirrhosis and healthy participants; diagnostic performance comparable to AFP (ROC/AUC reported). |
| Description: |
Plasma hsa_circ_0027089 is significantly up-regulated in HBV-related HCC and can distinguish HCC patients from HBV-related cirrhosis and healthy controls, showing diagnostic performance comparable to AFP. The study reports its genomic origin from PTGES3 and provides predicted miRNA binding partners, but does not experimentally validate a functional mechanism. |
| Confidence score: |
0.6556 |