circRNA basic information
circBase ID: hsa_circ_0041268
Name: hsa_circ_PRPF8
Synonym: -
Host Gene: PRPF8
Genomic location(hg19): chr17:1553922-1554250:-
Genomic location(hg38): chr17:1650628-1650956:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

BEAS‐2B; H1755; H1650; PC9; A549; HEK 239T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: miR-214-5p
Biological function: promotes NSCLC cell proliferation, migration, tumor formation and metastasis
Molecular mechanism: ceRNA sponge of miR-214-5p to regulate ROCK1
Biological pathway or process:

proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

could therefore be a novel NSCLC prognostic marker
Description:

hsa_circ_0041268 is up-regulated in NSCLC cell lines and promotes proliferation, migration, tumor growth and metastasis. Mechanistically, it acts as a ceRNA by sponging miR-214-5p to increase ROCK1 expression (hsa_circ_0041268/miR-214-5p/ROCK1 axis).
Confidence score:

0.6261
Other information
Title:

Hsa_circ_0041268 promotes NSCLC progress by sponging miR-214-5p/ROCK1.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35212425
Study type:

biological research
Data availability: -
Code availability: -