| Expression pattern: |
DN |
| Associated gene: |
CUL5 |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for vascular tumors and potential prognostic marker of angiosarcoma; functional role in oncogenesis remains unknown. |
| Molecular mechanism: |
Unknown; the study measured circ_0024169 expression and circ_0024169/CUL5 ratio, but did not experimentally define a molecular mechanism. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
circ_0024169/CUL5 ratio may be useful as a diagnostic biomarker for vascular tumors, whereas relative circ_0024169 levels may have potential as a prognostic marker of angiosarcoma; decreased relative circ_0024169 levels tended to show poorer prognosis but without statistical significance. |
| Description: |
This study found reduced circ_0024169/CUL5 ratio in angiosarcoma and pyogenic granuloma compared with other tumors or normal skin, suggesting diagnostic value for vascular tumors. Relative circ_0024169 levels in angiosarcoma tissues were explored as a prognostic marker, with decreased levels tending to associate with poorer prognosis, although the survival difference was not statistically significant. No specific molecular mechanism or interacting miRNA was experimentally validated. |
| Confidence score: |
0.5261 |