circRNA basic information
circBase ID: hsa_circ_0017545
Name: hsa_circ_AKR1C3
Synonym: -
Host Gene: AKR1C3
Genomic location(hg19): chr10:5140993-5149878:+
Genomic location(hg38): chr10:5098801-5107686:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0012004
MONDO name: parathyroid gland carcinoma
Disease details: parathyroid carcinoma
Disease DO ID:
 1540
Disease MeSH ID:
 -
Disease NCIt ID:
 C4906
Disease ICD11 ID:
 -
Disease OMIM ID:
 608266
Species: Human
Species details: Homo sapiens
Tissue specimen:

parathyroid carcinoma tissues; parathyroid adenoma tissues; normal parathyroid tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AKR1C3 mRNA
Associated microRNA: -
Biological function: hsa_circ_0017545 is upregulated in parathyroid carcinoma compared with parathyroid adenoma and positively correlates with AKR1C3 mRNA expression in parathyroid neoplasm tissues.
Molecular mechanism: circRNA-mRNA co-expression with AKR1C3 mRNA; potential involvement in parathyroid tumourigenesis.
Biological pathway or process:

other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circ_0017545 was dysregulated between PC patients with and without CDC73 inactivating mutations.
Description:

hsa_circ_0017545 is significantly upregulated in parathyroid carcinoma and correlates positively with AKR1C3 mRNA. The study suggests it may participate in circRNA-mRNA regulatory interactions during parathyroid tumourigenesis.
Confidence score:

0.4032
Other information
Title:

Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.

Journal: RNA biology
Published: 2019
PubMed ID: 31213128
Study type:

combined biological and clinical study
Data availability: available from the corresponding authors upon reasonable request
Code availability: -