circRNA basic information
circBase ID: hsa_circ_0035563
Name: hsa_circ_ANXA2
Synonym: -
Host Gene: ANXA2
Genomic location(hg19): chr15:60674540-60674640:-
Genomic location(hg38): chr15:60382341-60382441:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0012004
MONDO name: parathyroid gland carcinoma
Disease details: parathyroid carcinoma
Disease DO ID:
 1540
Disease MeSH ID:
 -
Disease NCIt ID:
 C4906
Disease ICD11 ID:
 -
Disease OMIM ID:
 608266
Species: Human
Species details: Homo sapiens
Tissue specimen:

parathyroid carcinoma tissues; parathyroid adenoma tissues; normal parathyroid tissues; FFPE samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ANXA2 mRNA, CDC73
Associated microRNA: -
Biological function: hsa_circ_0035563 is upregulated in parathyroid carcinoma, correlates with ANXA2 mRNA expression, and high expression is associated with CDC73 mutations and recurrence in PC patients.
Molecular mechanism: circRNA-mRNA co-expression with ANXA2 mRNA; potential involvement in parathyroid tumourigenesis.
Biological pathway or process:

other pathway/process (promotes)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

High expression of hsa_circ_0035563 was related to CDC73 mutations and recurrence in PC patients.
Description:

hsa_circ_0035563 is significantly upregulated in parathyroid carcinoma compared with parathyroid adenoma. Its expression correlates positively with ANXA2 mRNA and is associated with CDC73 mutations and recurrence, suggesting prognostic relevance in PC.
Confidence score:

0.4297
Other information
Title:

Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.

Journal: RNA biology
Published: 2019
PubMed ID: 31213128
Study type:

combined biological and clinical study
Data availability: available from the corresponding authors upon reasonable request
Code availability: -