| Expression pattern: |
UP |
| Associated gene: |
PARP2, AKT2 |
| Associated microRNA: |
miR-5095 |
| Biological function: |
circRAD23B promoted proliferation and invasion of esophageal cancer cells; circRAD23B knockdown increased apoptotic cells and inhibited cell proliferation and invasive ability. |
| Molecular mechanism: |
circRAD23B acts as a miR-5095 sponge and facilitates PARP2 and AKT2 expression, forming a circRAD23B/miR-5095/PARP2-AKT2 regulatory mechanism in esophageal cancer. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
circRAD23B was upregulated in esophageal cancer clinical specimens and may provide a novel insight into pathogenesis and a potential treatment strategy. |
| Description: |
circRAD23B is upregulated in esophageal cancer tissues and cancer cell lines. It promotes proliferation and invasion of esophageal cancer cells, acting through a ceRNA mechanism in which circRAD23B sponges miR-5095 to increase PARP2 and AKT2 expression. |
| Confidence score: |
0.7129 |