| Expression pattern: |
DN |
| Associated gene: |
SMAD4, E-CAD, N-CAD, VIM |
| Associated microRNA: |
miR-136 |
| Biological function: |
Suppresses EMT and metastasis (migration, invasion, lung metastasis); no significant effect on proliferation |
| Molecular mechanism: |
ceRNA mechanism: circ-OXCT1 sponges miR-136 to regulate SMAD4 and modulate TGF-beta/Smad-induced EMT markers (E-CAD, N-CAD, VIM). |
| Biological pathway or process: |
TGF-beta/SMAD (inhibits); EMT (inhibits); metastasis (inhibits); migration (inhibits); invasion (inhibits); proliferation (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; divergent primers PCR; Sanger Sequencing; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower circ-OXCT1 level indicated a shorter 5-year overall survival; expression correlated with lymph node metastasis and pathological stage. |
| Description: |
In gastric cancer, circ-OXCT1 is down-regulated and acts as a tumor suppressor for EMT and metastasis. Mechanistically, it sponges miR-136 in the cytoplasm to modulate SMAD4 and attenuate TGF-beta/Smad-driven EMT marker changes, reducing migration, invasion, and lung metastasis in vivo. Low circ-OXCT1 expression is associated with advanced clinicopathologic features and worse overall survival. |
| Confidence score: |
0.8557 |