| Expression pattern: |
UP |
| Associated gene: |
TNFRSF10A, KRAS, BRAF, EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Promotes CRC cell growth/proliferation and prevents apoptosis. |
| Molecular mechanism: |
CircRAPGEF5 suppresses TNFRSF10A expression by inhibiting RAS/RAF/MEK/ERK signaling (preventing pathway hyperactivation), thereby reducing apoptosis; EIF4A3 promotes circRAPGEF5 circularization. |
| Biological pathway or process: |
ERK (inhibits); apoptosis (inhibits); proliferation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Western Blot; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circRAPGEF5 is up-regulated in colorectal cancer, especially in KRAS-mutant CRC cells, and promotes CRC cell proliferation by preventing apoptosis. Mechanistically, circRAPGEF5 restrains RAS/RAF/MEK/ERK signaling to avoid hyperactivation, thereby suppressing TNFRSF10A induction and apoptosis; EIF4A3 enhances circRAPGEF5 biogenesis by promoting its circularization. |
| Confidence score: |
0.8166 |