| Expression pattern: |
UP |
| Associated gene: |
BRD4, MADD |
| Associated microRNA: |
miR-185-3p |
| Biological function: |
promotes NSCLC cell proliferation, migration, and invasion, and inhibits apoptosis |
| Molecular mechanism: |
circ_0074027 acts as a competing endogenous RNA that sponges miR-185-3p to elevate BRD4 and MADD expression at the posttranscriptional level |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
Overexpressed circ_0074027 was related to more advanced TNM stages, poorer differentiation grade, and worse overall survival; upregulated circ_0074027 was identified as an independent prognostic factor |
| Description: |
circ_0074027 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with advanced TNM stage, poorer differentiation, and worse overall survival. Functionally, circ_0074027 promotes proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-185-3p to increase BRD4 and MADD expression. |
| Confidence score: |
0.7628 |