circRNA basic information
circBase ID: -
Name: hsa_circ_SLC30A7
Synonym: hsa_circRNA_100290
Host Gene: SLC30A7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

oral cancer tissue samples; noncancerous tissue samples; oral tumor tissue specimens
Cell lines:

Tca8113; CAL-27; HEK293; primary gingival KCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GLUT1
Associated microRNA: miR-378a
Biological function: Promotes OSCC cell proliferation and glycolysis and inhibits apoptosis; circRNA_100290 silencing suppresses colony formation and glycolysis while increasing apoptosis.
Molecular mechanism: circRNA_100290 acts as a competing endogenous RNA for miR-378a, relieving miR-378a-mediated suppression of GLUT1 and thereby promoting glycolysis and proliferation in OSCC cells.
Biological pathway or process:

ceRNA regulation (other); glycolysis (promotes); proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; Western Blot
Clinical significance:

-
Description:

hsa_circRNA_100290/circRNA_100290 is up-regulated in OSCC tissues and cell lines. It promotes OSCC cell proliferation and glycolysis by acting as a ceRNA for miR-378a, thereby relieving miR-378a-mediated suppression of GLUT1; silencing circRNA_100290 suppresses glycolysis and colony formation and increases apoptosis.
Confidence score:

0.6479
Other information
Title:

Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR-378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter-1 (GLUT1) and glycolysis.

Journal: Journal of cellular physiology
Published: 2019
PubMed ID: 31187488
Study type:

combined biological and clinical study
Data availability: Table S1; Figure S1; Supporting Information
Code availability: -