circRNA basic information
circBase ID: hsa_circ_0043954
Name: hsa_circ_BRCA1
Synonym: cBRCA1
Host Gene: BRCA1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD-OR tissues; LUAD-OS tissues
Cell lines:

PC9OR; HCC827OR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

circRNA-seq
Clinical significance:

-
Description:

cBRCA1 (has_circ_0043954) was identified as down-regulated in osimertinib-resistant LUAD during sequencing-based screening, but functional assays did not show an effect on resistant cell growth under osimertinib compared with cLMNB1; no mechanism was established for cBRCA1 in this study.
Confidence score:

0.1848
Other information
Title:

The N6-methyladenosine-mediated cLMNB1 degrades FGFR4 to overcome osimertinib resistance in non-small cell lung cancer.

Journal: Cell death & disease
Published: 2025
PubMed ID: 41213916
Study type:

biological research
Data availability: GSA-Human: HRA007900
Code availability: -