| Expression pattern: |
UP |
| Associated gene: |
PTMA |
| Associated microRNA: |
miR-512-5p |
| Biological function: |
circ-0004277 promotes CRC cell proliferation and inhibits apoptosis; circ-0004277 knockdown restrains CRC cell growth in vivo. |
| Molecular mechanism: |
circ-0004277 acts as a miR-512-5p sponge to upregulate PTMA expression, thereby regulating CRC cell proliferation and apoptosis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ-0004277 expression was associated with advanced tumor stage, larger tumor size, and decreased overall survival in CRC patients. |
| Description: |
hsa_circ_0004277/circ-0004277 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with larger tumor size, advanced TNM stage, and poorer overall survival. Functionally, it promotes CRC cell proliferation and inhibits apoptosis, while knockdown restrains xenograft tumor growth. Mechanistically, circ-0004277 functions as a ceRNA sponge for miR-512-5p to upregulate PTMA expression. |
| Confidence score: |
0.7733 |