| Expression pattern: |
UP |
| Associated gene: |
CPEB4, AGO2 |
| Associated microRNA: |
miR-3666 |
| Biological function: |
promotes proliferation, migration, invasion, EMT, tumor growth and metastasis; promotes cisplatin (CDDP) resistance by regulating stem cell properties; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponging miR-3666 to upregulate CPEB4 signaling, promoting malignant progression and cisplatin resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); metastasis (promotes); stemness (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Colony Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry); IF (Immunofluorescence); TUNEL; H&E Staining; Western Blot |
| Clinical significance: |
High circ_0008315 expression predicted unfavorable survival outcomes and was an independent risk factor for OS and DFS in GC patients |
| Description: |
circ_0008315 (hsa_circ_0008315), derived from RASGRF2, is up-regulated in gastric cancer and further elevated in cisplatin-resistant models. It promotes proliferation, migration/invasion, EMT, metastasis, and cisplatin resistance by sponging miR-3666 to increase CPEB4 and stemness-associated phenotypes. High circ_0008315 expression is associated with worse OS/DFS and serves as a potential therapeutic (nanoparticle siRNA) target. |
| Confidence score: |
0.8933 |