| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1271 |
| Biological function: |
promotes breast cancer cell proliferation and progression, supports cell cycle progression, and inhibits apoptosis |
| Molecular mechanism: |
circ-ABCB10 acts as a miRNA sponge for miR-1271 in breast cancer tumorigenesis |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay |
| Clinical significance: |
- |
| Description: |
circ-ABCB10 is a human ABCB10-derived circRNA that is significantly up-regulated in breast cancer tissues and cell lines. It acts as an oncogenic circRNA by promoting proliferation and cell cycle progression while suppressing apoptosis, at least partly through sponging miR-1271. |
| Confidence score: |
0.7785 |