circRNA basic information
circBase ID: hsa_circ_0003519
Name: hsa_circ_ZEB1
Synonym: circ_0003519
Host Gene: ZEB1
Genomic location(hg19): chr10:31644075-31676195:+
Genomic location(hg38): chr10:31355146-31387266:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005595
MONDO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma / LSCC
Disease DO ID:
 2876
Disease MeSH ID:
 -
Disease NCIt ID:
 C4044
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

TU-177
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CASP10, TPO
Associated microRNA: miR-145-5p
Biological function: May participate in LSCC pathogenesis through miR-145-5p-centered ceRNA pathways related to apoptosis, stem cell features, and metabolic regulation.
Molecular mechanism: ceRNA mechanism involving miR-145-5p binding sites and CASP10/TPO-related regulatory axes.
Biological pathway or process:

ceRNA regulation (other); apoptosis (other); stemness (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003519 was identified as a high-degree circRNA in the miR-145-5p-centered circRNA-miRNA-mRNA ceRNA network in LSCC cells. The paper predicts that it may function through CASP10-miR-145-5p-circ_0003519 and TPO-miR-145-5p-circ_0003519 axes related to apoptosis, stem cell features, and metabolic regulation, but this circRNA was not individually validated by RT-qPCR.
Confidence score:

0.1768
Other information
Title:

Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.

Journal: Proteomics
Published: 2019
PubMed ID: 31169343
Study type:

combined biological and bioinformatics study
Data availability: Supplementary Table S2; Supplementary Table S5; Supplementary Table S6
Code availability: -