| Expression pattern: |
UP |
| Associated gene: |
NF-kappaB, Wnt/beta-catenin, CyclinD1, CDK6, Bcl-2, Bax, Cleaved/Caspase-3 |
| Associated microRNA: |
miR-154-5p |
| Biological function: |
circABCC4 promotes breast cancer cell viability, migration and invasion, and inhibits apoptosis; circABCC4 knockdown suppresses cell viability, migration and invasion and promotes apoptosis. |
| Molecular mechanism: |
circABCC4 acts as a ceRNA of miR-154-5p and promotes NF-kappaB and Wnt/beta-catenin signaling in breast cancer cells. |
| Biological pathway or process: |
NF-kappaB (promotes); Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circABCC4 may serve as a cancerous-gene in breast cancer progression. |
| Description: |
circABCC4 is up-regulated in breast cancer tissues and acts as a tumor-promoting circRNA in vitro. Its knockdown suppresses breast cancer cell viability, migration and invasion while promoting apoptosis, at least partly through up-regulating miR-154-5p and inhibiting NF-kappaB and Wnt/beta-catenin signaling pathways. |
| Confidence score: |
0.5732 |