circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001687
MONDO name: diabetic cataract
Disease details: diabetic cataract / DC
Disease DO ID:
 13328
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 340836242
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

DC lens tissues; transparent lens tissues; lens anterior capsular tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Significantly down-regulated in diabetic cataract lens tissues; the specific molecular regulation mechanism in diabetic cataract was not determined.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation
Clinical significance:

-
Description:

circHIPK3 was reported by this study's RNA-seq analysis as significantly down-regulated in diabetic cataract lens tissues. The paper did not validate this finding by qRT-PCR or define a diabetic-cataract-specific mechanism for circHIPK3.
Confidence score:

0.2995
Other information
Title:

Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function.

Journal: Gene
Published: 2019
PubMed ID: 31153886
Study type:

combined bioinformatics and clinical study
Data availability: RNA-seq data available from the corresponding author upon request
Code availability: -