| Expression pattern: |
UP |
| Associated gene: |
SIX1 |
| Associated microRNA: |
miR-1296-5p |
| Biological function: |
promotes cisplatin resistance and tumor growth; represses apoptosis; promotes proliferation, invasion, and migration in DDP-resistant NSCLC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0017639 sponges miR-1296-5p to elevate SIX1 expression |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); invasion (promotes); migration (promotes); tumor growth (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; MTT; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0017639 is overexpressed in DDP-resistant NSCLC samples compared to DDP-sensitive samples |
| Description: |
In DDP-resistant NSCLC, circ_0017639 is up-regulated and mainly localized in the cytoplasm. It promotes cisplatin resistance and malignant phenotypes by sponging miR-1296-5p, thereby increasing SIX1 expression, and its knockdown sensitizes tumors/cells to DDP and inhibits tumor growth in vivo. |
| Confidence score: |
0.7956 |