| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes colony formation; promotes migration; promotes tumor growth |
| Molecular mechanism: |
oncogenic factor; siRNA-mediated silencing using PPPCSs delivery system |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (other); ceRNA regulation (not specified) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Survival Analysis |
| Clinical significance: |
High circ_0058051 expression was negatively correlated with the prognosis of HCC patients; higher circ_0058051 expression was significantly correlated with vascular invasion, tumor differentiation, and TNM stage. |
| Description: |
circ_0058051 (derived from BARD1) is up-regulated in HCC tissues and mainly localized in the cytoplasm. Its silencing via siRNA (delivered by a magnetic SPION-based nanoplatform) suppresses HCC cell proliferation/colony formation and migration in vitro and inhibits xenograft tumor growth in vivo; high expression is associated with worse patient prognosis. |
| Confidence score: |
0.8079 |