circRNA basic information
circBase ID: hsa_circ_0000234
Name: hsa_circ_CUL2
Synonym: -
Host Gene: CUL2
Genomic location(hg19): chr10:35349801-35360267:-
Genomic location(hg38): chr10:35060873-35071339:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HeLa
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Identified as a differentially expressed circRNA and potential key player in cervical cancer after CXCR2 deficiency in HeLa cells.
Molecular mechanism: Associated with CXCR2 deficiency-related transcriptome changes and HIF-1 signaling pathway enrichment through its host gene CUL2.
Biological pathway or process:

HIF-1 signaling (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis
Clinical significance:

Potential key player in cervical cancer.
Description:

hsa_circ_0000234 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was linked to HIF-1 signaling pathway enrichment through CUL2 and validated by real-time PCR and Sanger sequencing.
Confidence score:

0.3858
Other information
Title:

Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.

Journal: Annals of clinical and laboratory science
Published: 2024
PubMed ID: 39855736
Study type:

combined biological and bioinformatics study
Data availability: -
Code availability: -