| Expression pattern: |
DN |
| Associated gene: |
HECT domain E3 ubiquitin protein ligase 1 (HECTD1), Heat Shock Protein 90 (HSP90) |
| Associated microRNA: |
miRNA-9 |
| Biological function: |
circDYM is reduced in plasma of MDD patients, increases after five-day visual cortical rTMS treatment, and may serve as a biomarker for MDD diagnosis and rapid antidepressant effect evaluation. |
| Molecular mechanism: |
Reported mechanism: circDYM acts as a miRNA-9 sponge, increases HECTD1 expression and HSP90 ubiquitination, and inhibits microglial activation; the mechanism of rTMS-induced circDYM upregulation was not revealed in this study. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (inhibits); inflammation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circDYM may help diagnose MDD and predict response and remission after visual cortical rTMS treatment; ROC AUCs were 0.643 for MDD diagnosis, 0.706 for predicting five-day rTMS response, and 0.799 for predicting one-month remission. |
| Description: |
This clinical study validated that plasma circDYM is significantly reduced in patients with major depressive disorder compared with normal controls. circDYM levels increased after five days of real visual cortical rTMS, and ROC analyses suggested potential diagnostic and treatment-response predictive value. |
| Confidence score: |
0.4187 |