| Expression pattern: |
UP |
| Associated gene: |
JAK2, p-STAT3, Ago2 |
| Associated microRNA: |
miR-375 |
| Biological function: |
promotes proliferation, migration, and invasion; inhibits apoptosis; promotes HCC progression |
| Molecular mechanism: |
circ_0072088 functions as a molecular sponge of miR-375 and activates the JAK2/STAT3 signaling pathway |
| Biological pathway or process: |
JAK/STAT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0072088 expression was associated with tumor size, the number of nodules, Edmondson grade, and TNM stage; it may provide a potential biomarker and therapy target for HCC |
| Description: |
circ_0072088 is up-regulated in HCC tissues and cell lines and is mainly cytoplasmic. It promotes HCC cell proliferation, migration, and invasion while inhibiting apoptosis by sponging miR-375 and activating the JAK2/STAT3 signaling pathway. Its expression is associated with aggressive clinicopathological characteristics, suggesting potential biomarker or therapeutic-target value. |
| Confidence score: |
0.7785 |