| Expression pattern: |
UP |
| Associated gene: |
TGFB1, Ago2, HK2 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
promotes GC cell growth/proliferation, metastasis (migration and invasion), glycolysis, and angiogenesis; inhibits apoptosis |
| Molecular mechanism: |
circ_0006089 acts as a ceRNA sponge for miR-361-3p to upregulate TGFB1, affecting downstream malignant phenotypes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); angiogenesis (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Microarray |
| Clinical significance: |
circ_0006089 might be a potential therapeutic target for GC |
| Description: |
circ_0006089 is up-regulated in gastric cancer tissues and cells and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion, glycolysis and angiogenesis while inhibiting apoptosis, largely via a ceRNA mechanism in which circ_0006089 sponges miR-361-3p to increase TGFB1 expression; knockdown suppresses tumor growth in xenografts. |
| Confidence score: |
0.8256 |