| Expression pattern: |
UP |
| Associated gene: |
LANA, RTA, TNF |
| Associated microRNA: |
miR-K12-10b |
| Biological function: |
Functions as an antiviral factor that suppresses KSHV latent and lytic viral gene expression without blocking viral entry; may stimulate host defense pathways. |
| Molecular mechanism: |
Predicted viral miRNA binding and antiviral regulation of KSHV gene expression; possible stimulation of host defense pathways and possible regulation of viral transcription through chromatin-related transcription factors. |
| Biological pathway or process: |
viral replication (inhibits); immune regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; circRNA-seq; Transfection; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0001400 is a human circRNA induced by KSHV infection. It suppresses KSHV LANA and RTA expression and acts as an antiviral factor, potentially through viral miRNA binding and stimulation of host defense pathways. |
| Confidence score: |
0.5971 |