| Expression pattern: |
DN |
| Associated gene: |
DAB2IP |
| Associated microRNA: |
miR-647 |
| Biological function: |
Acts as a tumor suppressor in CRC; overexpression suppresses CRC cell proliferation, migration, and invasion, induces G0/G1 cell cycle arrest, and impedes xenograft tumor growth in vivo. |
| Molecular mechanism: |
circFAM114A2 functions as a ceRNA/miRNA sponge by binding miR-647, thereby upregulating DAB2IP expression and suppressing CRC progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); cell cycle (inhibits); EMT (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
Low circFAM114A2 expression was associated with poorer survival of CRC patients; circFAM114A2 may serve as a potential biomarker and therapeutic target for CRC. |
| Description: |
circFAM114A2 is downregulated in colorectal cancer tissues and cell lines, and low expression is associated with poorer overall survival. Functionally, circFAM114A2 suppresses CRC cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a miR-647 sponge to increase DAB2IP expression, forming a circFAM114A2/miR-647/DAB2IP regulatory axis. |
| Confidence score: |
0.7793 |