| Expression pattern: |
UP |
| Associated gene: |
Ago2 protein, PTEN, Akt |
| Associated microRNA: |
miR-19a |
| Biological function: |
promotes osteosarcoma cell growth, proliferation and invasion; inhibits apoptosis |
| Molecular mechanism: |
circ_ORC2 binds miR-19a, enhances miR-19a expression/function, inhibits PTEN expression and activates Akt pathway |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; BrdU; Annexin V/PI Flow Cytometry; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0006101/circ_ORC2 is up-regulated in human osteosarcoma cell lines and is mainly cytoplasmic. It binds miR-19a and enhances miR-19a-mediated repression of PTEN, leading to Akt pathway activation, increased proliferation and invasion, and reduced apoptosis in osteosarcoma cells. |
| Confidence score: |
0.6853 |