| Expression pattern: |
UP |
| Associated gene: |
SLC38A1 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Promotes CRC cell viability, migration, invasion, angiogenesis, glutaminolysis and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-149-5p, thereby upregulating SLC38A1 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_0003602 level is associated with lower overall survival and positively correlated with TNM stage in CRC patients. |
| Description: |
hsa_circ_0003602 (circ_0003602/circSMARCC1) is upregulated in colorectal cancer and functions as an oncogenic circRNA. It sponges miR-149-5p to increase SLC38A1, promoting malignant phenotypes including proliferation/viability, migration/invasion, angiogenesis, glutaminolysis, and tumor growth while inhibiting apoptosis; high expression indicates poorer overall survival. |
| Confidence score: |
0.7892 |