circRNA basic information
circBase ID: hsa_circ_0000110
Name: hsa_circ_PTPN22
Synonym: -
Host Gene: PTPN22
Genomic location(hg19): chr1:114372213-114377061:-
Genomic location(hg38): chr1:113829591-113834439:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; tumour tissue; normal tissue; paracancer tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: PTPN22
Associated microRNA: -
Biological function: non-invasive diagnostic biomarker potential
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Potential as a non-invasive diagnostic biomarker (enriched in plasma B cells).
Description:

hsa_circ_0000110 (PTPN22) is highlighted via single-cell-based analysis as enriched in plasma B cells, suggesting potential utility as a non-invasive diagnostic biomarker for CRC, though the study does not report a specific up/down direction in bulk tumors.
Confidence score:

0.1768
Other information
Title:

Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.

Journal: Clinical and translational medicine
Published: 2024
PubMed ID: 39397316
Study type:

combined biological and clinical study
Data availability: PRJCA019939; GSE161277; GSE221240; GSE235850
Code availability: https://github.com/wangjun‐bio/miRlab/tree/CRC