| Expression pattern: |
UP |
| Associated gene: |
KRAS |
| Associated microRNA: |
miR-877-5p |
| Biological function: |
promotes the proliferation, migration, and invasion of CC cells in vitro and the growth of CC tumors in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0039787 sponges miR-877-5p to relieve inhibition of KRAS |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
ROC curve analysis demonstrated the diagnostic value of circ_0039787 in CC; circ_0039787 could serve as a promising diagnostic biomarker and potential therapeutic target for CC patients |
| Description: |
circ_0039787 is up-regulated in cervical cancer tissues/serum/cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes CC cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-877-5p, thereby increasing KRAS expression (circ_0039787/miR-877-5p/KRAS ceRNA axis). It also shows diagnostic potential by ROC analysis in patient serum. |
| Confidence score: |
0.8427 |