circRNA basic information
circBase ID: -
Name: mmu_circ_Fndc3b
Synonym: circFndc3b
Host Gene: Fndc3b
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

tumor tissues
Cell lines:

LL/2 (LLC)
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
UN
Associated gene: TFII-I, STAT1, CXCL10, CXCL11
Associated microRNA: -
Biological function: Promotes tumor progression and reduces CD8+ T cell infiltration in vivo; compromises anti-PD-1 therapy response.
Molecular mechanism: Binds TFII-I and disrupts TFII-I/STAT1 interaction, reducing STAT1 phosphorylation and downregulating CXCL10/CXCL11 in LLC cells.
Biological pathway or process:

immune regulation (inhibits); drug resistance (promotes)
Detected method:
Q
Validation methods:

FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); RT-qPCR; Co-IP; Western Blot; Transfection; In Vivo Animal Model; IHC (Immunohistochemistry); Flow Cytometry（Non-apoptosis/cycle）
Clinical significance:

-
Description:

In the mouse LLC syngeneic model, nuclear circFndc3b binds TFII-I and interferes with TFII-I/STAT1 signaling, suppressing CXCL10/CXCL11 and limiting CD8+ T-cell infiltration. This promotes tumor growth and reduces response to anti-PD-1 therapy.
Confidence score:

0.729
Other information
Title:

Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer.

Journal: Communications biology
Published: 2025
PubMed ID: 40341878
Study type:

biological research
Data availability: -
Code availability: -