| Expression pattern: |
DN |
| Associated gene: |
mRNA target genes |
| Associated microRNA: |
miR-10a-5p, miR-224-3p, miR-876-5p, miR-148b-3p, miR-30d-3p, miR-193a-3p, miR-579-3p, miR-499a-5p, miR-106a-3p, miR-1278, miR-30b-3p, miR-522-3p |
| Biological function: |
circHIPK3 suppresses ovarian cancer progression; its knockdown promotes proliferation, migration and invasion and inhibits apoptosis. |
| Molecular mechanism: |
Predicted ceRNA mechanism through the circHIPK3-miRNA-mRNA axis; circHIPK3 might function by sponging miRNAs. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
- |
| Description: |
circHIPK3 is down-regulated in epithelial ovarian cancer and functions as a tumor-suppressive regulator in this study. Its knockdown promotes proliferation, migration and invasion and reduces apoptosis, potentially through a predicted circHIPK3-miRNA-mRNA ceRNA network. |
| Confidence score: |
0.7618 |