| Expression pattern: |
UP |
| Associated gene: |
hexokinase 2 (HK2), HK2 |
| Associated microRNA: |
miR-513a-3p |
| Biological function: |
Promotes gastric cancer cell proliferation, tumor growth and glycolysis; knockdown of circBFAR inhibits proliferation and glycolysis in vitro and in vivo. |
| Molecular mechanism: |
circBFAR functions as a miRNA sponge for miR-513a-3p, thereby regulating HK2 expression and promoting proliferation and glycolysis in gastric cancer. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); ceRNA regulation (promotes); oxidative phosphorylation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circBFAR may serve as a novel target of GC individualized therapy. |
| Description: |
circBFAR is up-regulated in gastric cancer tissues and cell lines. It promotes GC proliferation, tumor growth and glycolysis by sponging miR-513a-3p and up-regulating HK2, suggesting a potential therapeutic target for individualized GC treatment. |
| Confidence score: |
0.7581 |