circRNA basic information
circBase ID: -
Name: hsa_circ_BRCA1
Synonym: BRCA1 circRNAs
Host Gene: BRCA1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor breast tissue; adjacent normal breast tissues / normal adjacent mammary tissue samples; FFPE
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: BRCA1 mRNAs
Associated microRNA: -
Biological function: Associated with a decreased circRNA/mRNA ratio in breast tumor tissue versus adjacent normal tissue.
Molecular mechanism: Imbalance (disequilibrium) between BRCA1 circular RNAs and BRCA1 mRNAs, consistent with competition between backsplicing and linear splicing.
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Lower BRCA1 circRNAs/mRNAs ratio in tumor breast tissue compared to adjacent normal tissue.
Description:

BRCA1-derived circRNAs show an overall decreased circRNA/mRNA ratio in breast tumor tissue compared with adjacent normal tissue, indicating a backsplicing/linear-splicing disequilibrium associated with breast cancer.
Confidence score:

0.3991
Other information
Title:

Disequilibrium between BRCA1 and BRCA2 Circular and Messenger RNAs Plays a Role in Breast Cancer.

Journal: Cancers
Published: 2023
PubMed ID: 37046838
Study type:

combined biological and clinical study
Data availability: Part of the data presented in this study are available on request from the corresponding author, due to the large number of raw files generated.
Code availability: -