| Expression pattern: |
UP |
| Associated gene: |
WEE1, MDR1, MRP1, Bcl-2, MMP9, Bax, cleaved-caspase-3, MMP2 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
circ-SNAP47 promotes DDP chemoresistance, colony formation, cell proliferation, invasion and xenograft tumor growth, and inhibits apoptosis in DDP-tolerant NSCLC cells. |
| Molecular mechanism: |
circ-SNAP47 functions as a ceRNA by sponging miR-625-5p to upregulate WEE1, thereby promoting DDP resistance and malignant phenotypes in DDP-tolerant NSCLC cells. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ-SNAP47 expression was higher in DDP-resistant NSCLC tumor tissues than DDP-sensitive tissues, suggesting association with resistance to DDP-based chemotherapy and potential as a target to reverse DDP resistance. |
| Description: |
circ-SNAP47 (hsa_circ_0016760), derived from SNAP47, is upregulated in DDP-resistant NSCLC tissues and DDP-tolerant NSCLC cells. It promotes cisplatin/DDP chemoresistance, proliferation, colony formation, invasion and xenograft tumor growth while suppressing apoptosis, mainly through a cytoplasmic ceRNA mechanism involving miR-625-5p and WEE1. Knockdown of circ-SNAP47 sensitizes DDP-tolerant NSCLC cells to DDP and may represent a potential therapeutic strategy for reversing DDP resistance. |
| Confidence score: |
0.786 |